DNA Pooling as a Tool for Case-Control Association Studies of Complex Traits.

Ahn,  Chul; King,  Terri M; Lee,  Kyusang; Kang,  Seung Ho

Genomics Inform > Volume 3(1); 2005 > Article

Review

Genomics & Informatics 2005;3(1): 1-7.

DNA Pooling as a Tool for Case-Control Association Studies of Complex Traits.

Chul Ahn, Terri M King, Kyusang Lee, Seung Ho Kang

¹Department of Medicine, University of Texas Medical School, Houston, TX 77030, USA.
²Samsung Advanced Institute of Technology, Seoul 135-710, Korea.
³Department of Statistics, Ewha Womans University, Seoul 120-750, Korea.

Abstract

Case-control studies are widely used for disease gene mapping using individual genotyping data. However, analyses of large samples are often impractical due to the expense of individual genotyping. The use of DNA pooling can significantly reduce the number of genotyping reactions required; hence reducing the cost of large-scale case-control association studies. Here, we discuss the design and analysis of DNA pooling genetic association studies.